r/interesting
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u/Negative_1by12_aura
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8h ago
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Just Wow Diabetes can finally be cured permanently!
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u/benjamelonCM
8h ago
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This makes no sense. T2D don’t suffer from low insulin production. Also, for T1D, we’ve known for a while how to make beta cells from stem cells. What we need to figure out is how to stop the immune system of T1D patients from trying to destroy them.
T2D is an insulin receptor disorder. T1D is an auto immune disease. Neither problems are solved by pancreatic stem cells.
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u/MargaritaKid 7h ago •
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This is one of the million "see what awesome thing China is doing that the US isn't" posts on Reddit
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u/Iguana_Enthusiast 6h ago
And it works. It gets thousands of upvotes... Might be botted as well, but it's still working.
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u/couldbeahumanbean 7h ago
50¢ army filling the void left by the blown up Russian trollbot farms
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u/BurdTurglary 8h ago •
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Sensationalized text above two stock photos is misleading?! Well i never...
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u/Restart_from_Zero 7h ago
Pretty sure "in mice" was supposed to be in there somewhere, too.
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u/EvenBroaderBand 1h ago
T2D isn't one single illness some T2D are resistant to insulin while others produce reduced amounts of it.
T1: Can't product insulin because immune system kills the cells that produce it.
T2: Body becomes resistant to insulin or the body produces lower amounts of insulin for reasons different from T1.
Type 2 is basically "Anything other than Type 1".
Is good example of why we listen to actual experts and not just random redditors, good job the voting system is doing its job and this is downvoted to oblivi.....oh it has 600 upvotes.
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u/CauliflowerBig2311 29m ago
Type 2 is basically "Anything other than Type 1".
This kinda has been changing. My daughter was diagnosed as type 3C. However, treatment is the same as type 2 and it's not every healthcare provider that understand what 3C means, so usually we just say she has type 2...
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u/Unsold_Leave 3h ago
As a T1D myself, I have come to realize that the world was done a major disservice by both conditions being named nearly the same thing. They're so different, and about 90% of the population only knows the bare bones basics of specifically T2. The number of times I get told to "Just diet and exercise better". Brother I run marathons and eat an extremely self-restricted diet. My pancreas is non-functional.
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u/StaplerUnicycle 7h ago
I've been a T1 diabetic for more than 40years.
If seen/heard this line thousands of time over the years.
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u/Yangoose 5h ago
Remember like 20 years ago when lettuce was gonna cure T1?
https://www.diabetesincontrol.com/lettuce-may-be-the-next-big-diabetes-treatment/
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u/NotAzakanAtAll 4h ago
Looked into it.
This time a few diabetics who this was tested on has lived without any treatment for over a year. So if that's true it's something.
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u/GardeniaInMyHair 3h ago
If T1D was actually cured, we'd be hearing it from my sister's endocrinologist, not a Reddit post. Millions have been waiting for a cure, and if true, it would have spread like wildfire. The T1D community has been pretty quiet. So I'm going with a no on this one. Logic.
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u/nevicar_ 8h ago
T2D is often a composite of resistance and reduced production of insulin. It isn't always a clean clinical picture.
As for T1D, it depends if the new stems cells have different MHC proteins or some way to obfuscate T cell recognition pathway for the target beta cells. I dont know anything about this news from china so cant tell if its gonna work that way.
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u/Evignity 28m ago
Anytime you hear a bombastic scientific claim, wait for the peer-reviews.
It's like that time S.Koreans said they had made room-temperature superconductors. It was on world-news for days if not weeks before getting disproven.
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u/basicnecromancycr 8h ago
Some stock photos and a text make no sense after all. No source etc. given.
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u/C_Bergnaum 7h ago
Late-stage type 2 can eventually burn out the pancreas from overproducing insulin to compensate for resistance, which is usually when they become insulin-dependent. But calling it a flat out "permanent cure" for both types in general pop headlines is definitely massive overselling.
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u/Facerolla_1337 2h ago
T1 and T2 are not that cut and dry. T2 for example can be as a result of damage to the pancreas (either trauma or from diet abuse) and can still produce a tiny amount of insulin. It may have nothing to do with a receptor disorder, otherwise direct insulin injections wouldn't work...
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u/angilnibreathnach 1h ago
A pancreas transplant can restore normal glucose functioning so I suppose this works in the same way.
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u/Worms_blink 1h ago
Yes but you need immuno-suppressive drugs for life, otherwise the same thing happens and your beta cells get destroyed by the immune system and the T1 diabetes is back.
Current research is looking at somehow isolating beta cells from the immune system, eg through implanting them in hydrogels and injecting the whole thing into the patient.
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u/Drfilthymcnasty 7h ago
Over the time type 2’s beta cells burnout and there insulin output decreases over time.
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u/New_Response_7488 4h ago
People keep mixing up insulin resistance with insulin deficiency. T1D and T2D have very different underlying mechanisms, so treating them as the same problem misses the whole point.
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u/Negative_1by12_aura 8h ago
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u/Nax_Jello 8h ago edited 8h ago
These are trials not cure , your post is misleading no cure has been made till now ,only trials have been done on few people, these are trials result were published in 2024 , and u are posting these in 2026
pls dont give false hope to people suffering from this disease , trials takes years to became a cure in real life , its a offcouse a positive step but not cure
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u/SemiAnonymousTeacher 7h ago
This just sites three other studies... only ONE of which was from China. So why is only China mentioned in this Twitter post (rhetorical question- I know why)? Also, why not mention the dozens of similar studies using stem cells from before 2024? Universities in the US, UK, and India have all done this.
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u/Radiant-Ad-3134 8h ago edited 8h ago
I thought type II has insulin resistance. Not the problem of producing insulin (at least not the root problem).
Anyway, thanks for sourcing the paper
Edits, typo
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u/lemoinem 8h ago
I wouldn't trust not expect a Twitter screenshot to deal with accuracy or nuances.
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u/AppropriateDraft5039 5h ago
Too late, already dumped all my metformin in the trash and sucking back a bottle of maple syrup.
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u/SomeDumbDoggo 3h ago
its almost like uninformed people make uninformed takes lol. There's a reason we say "don't believe anything you hear and only half of what you read"
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u/smoothoperator_64290 6h ago
Diabetes is a complicated condition, type 2 diabetes is exactly that. Insulin hyper resistance. Your pancreas responds by making more insulin. Over time this can stress the pancreas to the point where it can actually start to produce less insulin to the point of cessation. Type 2 Diabetics can become insulin dependent just like a Type 1 Diabetic. Type 1 Diabetes is primarily an autoimmune disorder where the immune system actually destroys the insulin producing cells very early in their life cycle before they can do their job. There are multiple other types of Diabetes as well beyond Gestational Diabetes which is the other form most people are familiar with.
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u/The_Reset_Button 5h ago
I have what looks like type 2 but is actually caused by a genetic mitochondrial mutation called "Maternally Inherited Diabetes and Deafness", or MIDD. You can also have MODY (Mature onset Diabetes of the young)
Basically if you have diabetes it just means you cannot control your blood sugar. Type 1 and type 2 don't describe how you got it but how it presents in a person
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u/FourDimensionalTaco 5h ago
Some people actually have suggested to rename type 1 and 2 to better emphasize how vastly different they actually are. It is like calling two hugely different skin conditions very similar names just because both produce a red rash.
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u/Dominotter 6h ago
Type 2 is a combination of insulin resistance and inadequate insulin production. This would only help with the latter part. Production generally worsens over time with T2 and some people get close to the Type 1's total loss of insulin production.
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u/nelrond18 8h ago
I was just gonna comment the same thing. Would be cool if you could reset insulin resistance
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u/polopolo05 7h ago
GLP1s, they can actually put DM2 into a "remission". like a reset. If you can change metabolic pathways in the dna that increase the likelyhood of DM2.... then you can cure it. Some families are more prone to it.
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u/gottagotothebathroom 4h ago
And with Type 1, the body's immune system would kill these cells off and stop insulin production again, which is what happens the first time.
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u/R_Prime
8h ago
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Let’s see how unaffordable the powers that be decide to make it.
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u/Fooligoo 8h ago
It’s China, not US. If China can’t make it affordable, nobody can.
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u/CaptainSebT 8h ago •
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Every single post on medical breakthroughs people like "Let's see how unaffordable they make it" just have better healthcare.
Because like I'm in Canada if someone cures diabetes you know Canada will do everything in there power to get every suitable patient to take the cure. You know because otherwise they front the bill over an entire life time.
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u/Winter_Success2909 7h ago
Insulin was first discovered in Canada and they gave to US out of his goodwill, ended up being this cluster fuck.
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u/CaptainSebT 7h ago
For the US. In Canada the yearly cost is much lower. I think the government should cover it but regardless it's much lower.
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u/redspadesX 7h ago •
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See if china is actually capable of doing this and it's not just another smoke and mirrors act
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u/deviantdevil80 7h ago •
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This right here... 99% of the "China did X" is all crap that never goes anywhere, ever...
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u/Nondescriptish 7h ago
Big Pharma will buy the patents and kill it. Cures are bad for business.
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u/SVlad_667 7h ago
China doesn't give a damn about American patents. But if the stupid American Laowai wants a patent - China will send him a patent from Temu.
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u/Rhorge 8h ago edited 8h ago
Any source on that? Pancreas damage is one thing, but type 1 is an autoimmune disease and I don’t see how stem cells can alter the behaviour of all white blood cells
Edit: after a brief read, the cells created by the treatment are generally located in the liver and other abdominal organs, hence the efficacy in type 1 patients.
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u/Fooligoo 8h ago
This might help: https://pmc.ncbi.nlm.nih.gov/articles/PMC11662597/
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u/Expert-Tea9960 5h ago
I feel like they didnt really talk about the science behind it, they talked about cases where it happened and i don‘t even think they were the ones doing it, just writing about it. Theme looks interesting enough though, i‘ll probsbly google it later, thank you anyway
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u/Dominotter 6h ago
I also don't think anyone has had the treatment yet that wasn't also on immune system suppression.
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u/RadicalSoda_ 7h ago
It's gene therapy essentially
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u/AlbertSciencestein 6h ago
No, it’s cell therapy. The man-made beta cells are injected into the abdomen, and these cells produce insulin. Gene therapy would involve changing the person’s genes within their body, and this isn’t that.
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u/karma_the_sequel
8h ago
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Link to a credible source or it didn’t happen.
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u/Gold-Public-1335 8h ago
There's a pixelated image of a biomolecule, a scientist, and a medical personnel with stethoscope. Therefore it is true. Duh
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u/LivingFrosting6680 7h ago
This is the Chinese media hype cycle. “China does X scientific miracle”, then everyone glazes China (and shits on America for no reason), then nothing ever comes of it because it was all made up in the first place.
Bonus points if there’s actually a source like a scientific paper that everyone just takes for granted, but later turns out to be completely false and irreproducible. People think if it’s in a scientific paper it must be true, but that’s not the goal in science. The goal is for other scientists and engineers to be able to actually make use of the information, which requires it to be true in the first place.
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u/PossiblyAsian 4h ago
truly the death of reddit
this post is facebook boomer type shit I see on facebook all the time
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u/LogoPro_15
5h ago
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Partly true, but "cured permanently" goes too far. The post is based on real Chinese research from 2024, but each result came from a single patient.
What actually happened
Type 1: A 25-year-old woman from Tianjin has not needed insulin injections for more than a year after receiving a stem cell transplant using her own reprogrammed cells. The Peking University team published the paper in Cell.
Type 2: A separate group in Shanghai transplanted insulin-producing islets into the liver of a 59-year-old man with type 2 diabetes, and he has since stopped taking insulin.
Why it's not a cure yet
That's one patient for each type, followed for a year or a few years. No one knows yet if the cells keep working for life.
In type 1, the body's immune system is what destroyed the insulin cells to begin with. The transplanted islets could still be targeted for destruction by the immune system. The type 1 patient was already taking immune-suppressing drugs because of an earlier liver transplant, so her case may not apply to most patients.
None of this is approved or available to the public.
The furthest-along option is Vertex's zimislecel, tested in the US and other countries. It enabled 83 per cent of trial participants to stop using insulin entirely within a year of receiving the full dose, but the patients also received immunosuppressive therapy to prevent the body from attacking the newly introduced islet cells. That trial also was limited by its small cohort, and a larger trial is now underway.
Bottom line: this is real and promising progress. A permanent cure that most diabetics can actually get is still likely years away.
Sources:
Live Science: Type 1 reversed using reprogrammed fat cells
Tec Science: Stem cells reverse diabetes
The Week: Zimislecel trial results
Business Today: Zimislecel in NEJM
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u/writingpracticeman 1h ago
I have a coworker who had an islet cell transplant as a part of a study out of the University of Chicago. What she has to go through is, honestly, not much better than just living with T1D. Apparently some of the other study members just said fuck it and (under medical supervision) stopped taking their anti rejection meds which just results in having T1D again.
So it's a cure, but it's still not much better vis quality of life.
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u/lightweight65 8h ago
Diabetes is a very very very very very long way from being cured.
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u/lovelaughlexapro 2h ago
The truth is China makes wild claims about advancements they make in just about everything while in actuality are cutting costs/corners everywhere and are only concerned with optics. I’m doubting how real this is.
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u/Classic_End_6469 7h ago
As a type 1 diabetic muthafucka… the first thing I’d do would almost certainty lead to diabetes again…
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u/Devilpig1
7h ago
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As an American i can't wait to see how they make it so expensive that only celebrities that don't need it become the only people who can afford it and use the entire supply for some quirk beneficial side effect that they don't really need so the rest of us can just go suffer and die somewhere.
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u/DrPhilSideSkirts 2h ago
If that turns out to be the case. Get your ass over to Europe. The flight + treatment will be cheaper here than staying in the US.
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u/Antique-Resort6160 1h ago
I had a friend recover from severe type 2 diabetes with stem cells.
It's funny because he got stem cell therapy for his knee, he could barely walk and used a cane or wheelchair sometimes. Walks fine and moves like a younger man now, and stopped injecting insulin. It's like a miracle cure for $6000 in japan, 30 minutes infusion and decades-long problems healed in a couple weeks. Wild stuff.
The US regulates the number of stem cells you can get in one infusion, making it very ineffective and crazy expensive if you want multiple treatments. people with money dont bother, theyve been getting stem cell therapy in mexico, europe, asia, etc for decades already.
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u/thorsten139 5h ago
It's an American problem.
Nobody pays so much for insulin. And as such the price people pay for a permanent cure will be alot lesser than in the states
It's a problem you guys create for yourselves.
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u/Bobthemouse 5h ago
Well in fairness in this case I think it's mostly the evil rich folk who profit off of suffering that are making this a problem, it's not a societal issue like pretty much everything else wrong with america
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u/stydlivalia 5h ago
they'll probably find a way to rebrand it as a wellness injection and charge triple for the aesthetic packaging
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u/SaltyAnimator5229 7h ago edited 7h ago
Type two diabetes can be put in remission by exercising and losing weight. It’s the high body fat % that makes the body insulin resistant. Meaning you still produce insulin but it does nothing. This isn’t my own words, it’s from an article I read.
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u/_R0Ns_ 6h ago
I know a guy who has type 2 and he is not fat, not even overweight.
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u/Ripley_and_Jones 1h ago
In the early stages yes. Later when the pancreas has totally failed, no.
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u/WorldlinessSevere717 7h ago
don't think advanced diabetes can be cured by exercise alone, because the beta cells that produce insulin are already dead.
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u/Only8livesleft 6h ago
After years of excess insulin production beta cells can fatigue and die. T2 doesn’t always lead to beta cell death and it’s a different mechanism than T1 but the treatment of regenerating them may be the same
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u/enjoyingcatsthankyou 6h ago
US company, Vertex, did the exact same thing and published over a year ago https://www.nejm.org/doi/abs/10.1056/NEJMoa2506549
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u/Runktar
7h ago
edited 6h ago
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Article is bullshit most diabetes is caused by insulin resistance which means the body makes insulin it's just not as effective as it should be. Add this to the list of articles about the things china has done recently including curing cancer cracking cold fusion effective humanoid robots etc etc etc.
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u/Sogelink 8h ago
I dunno if it would work for me, I lack insulin but while I'm treated like a diabetic, it's just because I lost a few chunks of my pancreas (I'm clumsy).
So it's not that my pancreas isn't working, it's just that I don't have enough of it to live without insulin (or enzymes too). Hope it could work on my case.
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u/the_jdi 5h ago
The LUCM (Leiden UMC) in The Netherlands have been doing this for the past 3 years now. The issue as said below is not growing (or transplanting) pancreatic cells but keeping the body from attacking its own cells. Hence the Auto immuno disease thing. They estimate another 8ish years before they can reliably and effectively 'hide' these cells but not 'loose' them in the body. One of the risks of hiding them to well is 'what if they then become cancerous and he don't know how to find them'-worries.
There is still a lot do to but progress is there.
For more information Nijhoff, M.F and Koning, E.J.P. d research papers.
https://www.diabetesfonds.nl/onderzoeken/nieuwe-eilandjes-van-langerhans-uit-stamcellen-maken
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u/imtiredofthisgrampaX 5h ago
Google the article. It's not as clean as this stupid post makes it sound.
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u/khoawala
7h ago
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Here's for those braindead who have been too mentally conditioned with "china bad" narrative:
https://pmc.ncbi.nlm.nih.gov/articles/PMC11662597/
https://finance.yahoo.com/news/chinese-medical-team-enables-30-092400922.html
The real news is China did reverse type 1 diabetes where the body can produce insulin again and patients have been going for over a year now without insulin injection.
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u/lithium142 6h ago
tell me you have no idea what type 1 diabetes is without telling me you have no idea.
thats a fine solution for type 2. it does fuckall to "cure" type 1 since type 1 is an autoimmune disorder. you can treat the insulin issues all you want, until you can reverse the autoimmune issue, they will need lifelong treatment. So all this is doing is replacing a cheap, self managed treatment, to an expensive one they have to regularly go to the hospital to have administered.
maybe people would have a higher opinion of the chinese state if they'd stop pushing these false narratives
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u/Enterovirus71 5h ago
First paper is a couple of indians? Also how many times are you going to spam this wumao
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u/BeefistPrime 6h ago edited 4h ago
I want to upvote you because you brought a source, but I want to downvote you because you were a massive asshole for no reason towards people who doubted an out of context, unsourced tweet about a medical cure
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u/Yossarian216 6h ago
There’s a human trial going on right now in the US that has also seemingly cured type one diabetes, don’t know if it’s the same treatment as China. The US one is a new anti-rejection drug that lets patients keep the islet cells that produce insulin without causing the secondary damage that typical anti-rejection drugs cause.
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u/SpendPerfect5933 6h ago
That’s the claim. The key issue is whether stem cell treatment has to be regular or is a one time process. If the former it’s meaningless as stem cell therapy is more expensive than insulin injections.
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u/Renard_Fou
6h ago
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Its China, so take the legitimacy and viability with a grain of salt
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u/Jojofan_lol 6h ago
All of that translates to “my country/economic block rivals China economically so I have to tag along with the hate train”
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u/CrawlerCharles 5h ago
I mean in the last 10 years how many “breakthroughs” have China had in medical science that haven’t gone anywhere at all because it’s just a sensationalized article. China has cured cancer every year for the last decade … yet
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u/Superseaslug 6h ago
I will believe it when they can give results. So many things China has claimed and not produced.
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u/hare-hound 5h ago
Uh not saying Chinese medical development is better or worse than the US, but if the US had managed to relax from pearl clutching to allow stem cell research and was supportive enough of medical research enough to pull this off, this still would have gotten buried by Big Pharma. The insulin costs (and rate and severity of diabetes) here is astounding. Absolutely despicable. For profit medical systems are evil.
So just want to point of how there are multiple layers of culture and science and politics that allowed this to happen.
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u/OnodrimOfYavanna 58m ago
The US doesn't pearl clutch about stems cells, and hasn't for years, and therapies like this ar developed in the US constantly
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u/lithium142 6h ago
claiming they've reversed both type 1 and type 2 with the same thing tells you all you need to know about the legitimacy of this lol. anybody with type 1 will immediately know this is bullshit
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u/ChemistryFan29 6h ago
Um it is possible with using stem cells to recreate pancreatic cells that can produce insulin then it is very possible to treat T1D, or if you regrow cells that have functional receptors to insulin then it is possible to cure type 2.
But turning stem cells into other cells is tricky. And very hard to do
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u/lithium142 6h ago
recreating pancreatic cells doesnt stop the body from killing them again. type 1 is an autoimmune disorder. until you fix that, the absolute best this does is replace self-managing insulin with regular trips to the hospital for this treatment. that is not a cure.
Modern passive management systems for diabetics allow them to live nearly normal lives these days. This would replace that with regular trips to the hospital for treatment. and that's BEST case scenario, and assuming it's not dramatically overstated like these "cures" always are.
type 1s have seen these papers come and go for decades. this has all the telltale hallmarks of yet another "cure". The biggest being the lumping of type 2 and type 1 together. They arent similar
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u/SingularityII 8h ago
Best part about this - I won't have to hear my father-in-law say "well, I got the diabee-dahs" anymore.
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u/Mental-Article-4117 7h ago
Coming to the US for only 10 low payments of $10.4M with insurance!!!! Yayyyyy
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u/BigJJsWillie 7h ago
Fuck yes, I'm gonna go buy myself a family size pack of super stuft oreos right this second!!!
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u/Bulky_Midnight8238 7h ago
Uhm.. thats not how type 2 works. Type 2 is an inability by the body to take in n process insulin
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u/TheWesternDevil 7h ago
Yay! Another cure for something horrible that us Americans will never be able to afford! Yay!
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u/Temporary-Sound-6810 7h ago
I have to take in large quantities of ice cream because my body doesn’t produce enough of it on its own.
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u/Windfade 7h ago
Did they also cure all cancers and use stemcells to reverse gender expression overnight?
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u/Oldnbold22 6h ago
I hope Chinese IQ can help humanity a lot this century. Other high IQ groups have only sought to profit from humanity in the past.
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u/Schuperman161616 6h ago
It will only stay in China, maybe Russia and Iran if they're lucky. No way in hell will the US allow a billion dollar disease disappear and will also sanction other countries that don't subscribe to the business model.
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u/NicottiZ 6h ago
Even if they can make new beta cells for producing insulin, that doesn't cure type 1. They have to insure the immune system doesn't attack the new cells.
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u/Mikelitoris88 6h ago
lol what is this garbage ? The statements are ami scentific and why tf does it look like a meme ?
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u/LeftAndRightAreWrong 6h ago
The biggest block for stem cells is that pharma can’t make money from it.
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u/BeefistPrime 6h ago
These are always bullshit. If not pure bullshit, they're taken out of context by an ignorant public, like, we have one effective treatment in rat and pigs that still has 15 steps to go until it's an actual medicine in humans and it will likely fail one of those steps. You guys believe everything and then make a conspiracy out of it when the bullshit you believed didn't come to fruition
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u/rufos_adventure 6h ago
there was a place in canada doing this ten years ago. maybe edmonton? i don't remember for sure.
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u/Adventurous_Touch342 6h ago
And the therapy will be only a billion dollars in US (and almost free anywhere else in the world).
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u/Squirty42069 6h ago
Type 1 here:
Doubt it, but it'd be cool. I've been hearing the same headline, over and over, every single year.
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u/MorganPerson1966 6h ago
Until we see a big bold heading in every leading newspaper on the planet - this is all hogwash. There’s a cure invented every year. Anyone TRULY curing Diabetes will be an earth shattering news given the sheer number of human beings this will impact. The news wont be a one time bruahaha - but constantly reinforced for months - given how massive this will be.
Its why I take these announcements with skepticism
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u/humanreporting4duty 6h ago
So we could have been researching this for 25 years if we had just approved stem cell research…
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u/TwisterSinister 5h ago
This news is two years old; the real question is when it will actually see widespread use.
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u/Effective-Dig-7091 5h ago
and how is the the generos donator ??? is he a doctor or prisoner? science without humanity is cruelty!!!!
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u/Professor-Stark 5h ago
No you will not see this in market, the funding for this research will be stopped and in worst case these scientists could disappear. This has happened before with cancer cure. Diabetes is a leading money making business as patient have to take medicine everyday for their life. This is CAPITALISM...
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u/fingertipoffun 5h ago
For 20 years i've been hearing this in one form or another. It's like free energy. No one is going to bother as there is no money in it.
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u/SadMap7915 5h ago
Meanwhile, in America, RFK Jr. (Secretary of Health and Human Services) claimed that "a baby normally lives inside the placenta".
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u/Psilonemo 5h ago
The economic benefit of making a treatment for diabetes universally available for a cheap price is considered an externality. But the economic benefit of creating a cartel arround its profit centered gatekeeping is all the rage.
China will likely make this cheap and universally available because the economic benefits in efficiency and productivity will be greater that way.
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u/JetstreamGW 5h ago
Okay but type 2 diabetics still produce insulin. So what does it do for type 2 diabetics?
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u/GlenGlenDrach 5h ago
So still fat, but live longer?
How about a treatment that takes away the hunger for sugar?
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u/Aromatic-Thing-132 4h ago
I feel like this is a great achievement we don't want to look too deeply into how it was developed.
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